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Amlodipine/atorvastatin (By mouth)

Amlodipine Besylate (am-LOE-di-peen BES-i-late), Atorvastatin Calcium (a-tor-va-STAT-in KAL-see-um)

Treats high blood pressure and angina (chest pain), and lowers high cholesterol levels. Helps prevent chest pain, stroke, heart attack, or heart and blood vessel diseases in people who are at high risk for these diseases. This medicine contains a calcium channel blocker (CCB) and an HMG-CoA reductase inhibitor (statin).

Brand Name(s):

Caduet

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to amlodipine or atorvastatin. Do not use this medicine if you have active liver disease, or if you are pregnant or breastfeeding.

How to Use This Medicine:

Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take this medicine at the same time each day.
  • Swallow the tablet whole. Do not break, crush, or chew it.
  • Carefully follow your doctor's instructions about diet and exercise. This medicine is only part of a complete plan for lowering cholesterol and triglycerides in your blood.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If more than 12 hours have passed since you missed your dose, then skip the missed dose and take your next dose at the time you normally would. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use birth control pills, cimetidine (Tagamet®), colchicine (Colcrys®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Lanoxin®), diltiazem (Cardizem®), niacin (vitamin B3), rifampin (Rifadin®, Rimactane®), or spironolactone (Aldactone®). Make sure your doctor knows if you also use medicine to treat hepatitis C (such as boceprevir, telaprevir, Victrelis®, Incivek®), medicine to treat an infection (such as clarithromycin, erythromycin, fluconazole, itraconazole, ketoconazole, Diflucan®, Nizoral®), medicine to treat HIV infection (such as darunavir, efavirenz, fosamprenavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir, Kaletra®, Norvir®), or other medicine to lower cholesterol (such as fenofibrate, gemfibrozil, Lopid®, Tricor®).
  • Tell your doctor if you usually drink more than 2 alcoholic drinks per day.
  • Tell your doctor if you regularly drink grapefruit juice or eat grapefruit.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you have kidney disease, diabetes, muscle problems, thyroid problems, or a history of liver disease. Tell your doctor if you have heart or blood vessel disease, low blood pressure, heart valve problems, or history of stroke.
  • Stop using this medicine and call your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have unusual tiredness or a fever. These could be symptoms of a serious muscle problem called myopathy. Tell your doctor if the muscle pain or weakness does not go away.
  • Call your doctor right away if you have dark urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems.
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
  • Check with your doctor right away if you have chest pain that is worse than usual, trouble breathing, nausea, unusual sweating, faintness, or pain in your arms, jaw, back, or neck.
  • Make sure any doctor or dentist who treats you knows that you use this medicine. You may need to stop using this medicine if you have major surgery, a major injury, or other serious health problems.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate, painful urination
  • Chest pain (may be related to your disease and not a side effect)
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Muscle pain, tenderness, or weakness
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unexplained fever, unusual tiredness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, upset stomach
  • Joint pain
  • Mild swelling in your hands, ankles, or feet

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014
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